https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Induction of caspase-mediated apoptosis in HepG2 liver carcinoma cells using mutagen-antioxidant conjugated self-assembled novel carbazole nanoparticles and in silico modeling studies https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45243 1H nuclear magnetic resonance, dynamic light scattering (DLS), and transmission electron microscopy techniques. The CT-capped gold nanoparticles (CTAuNPs) were prepared from CT, chloroauric acid, and NaBH₄. The CTAuNPs were characterized using ultraviolet–visible, high-resolution TEM, DLS, and Fourier transform IR techniques. The cytotoxicity and apoptosis-inducing ability of both nanoparticles were determined in HepG2 cells. The results demonstrate that CTNs exhibit antiproliferative activity in the cancerous HepG2 cells. Moreover, molecular docking and molecular dynamics studies were conducted to explore the therapeutic potential of CT against human EGFR suppressor protein to gain more insights into the binding mode of the CT, which may show a significant role in anticancer therapy.]]> Wed 26 Oct 2022 15:56:50 AEDT ]]> Induction of caspase-mediated apoptosis in HepG2 liver carcinoma cells using mutagen-antioxidant conjugated self-assembled novel carbazole nanoparticles and in silico modeling studies https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45239 1H nuclear magnetic resonance, dynamic light scattering (DLS), and transmission electron microscopy techniques. The CT-capped gold nanoparticles (CTAuNPs) were prepared from CT, chloroauric acid, and NaBH₄. The CTAuNPs were characterized using ultraviolet–visible, high-resolution TEM, DLS, and Fourier transform IR techniques. The cytotoxicity and apoptosis-inducing ability of both nanoparticles were determined in HepG2 cells. The results demonstrate that CTNs exhibit antiproliferative activity in the cancerous HepG2 cells. Moreover, molecular docking and molecular dynamics studies were conducted to explore the therapeutic potential of CT against human EGFR suppressor protein to gain more insights into the binding mode of the CT, which may show a significant role in anticancer therapy.]]> Wed 26 Oct 2022 15:56:20 AEDT ]]> Clinicopathological significance of nerves in esophageal cancer https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:37859 P = 0.04). The surrounding or invasion of nerves by cancer cells (perineural invasion) was detected in 12% of esophageal cancers and was associated with reduced survival (P = 0.04). Nerves were found to express the following receptors for nerve growth factor (NGF): neurotrophic receptor tyrosine kinase 1 and nerve growth factor receptor. An association was suggested between high production of NGF by cancer cells and the presence of nerves (P = 0.02). In vitro, NGF production in esophageal cancer cells was shown by Western blot, and esophageal cancer cells were able to induce neurite outgrowth in the PC12 neuronal cells. The neurotrophic activity of esophageal cancer cells was inhibited by anti-NGF blocking antibodies. Together, these data suggest that innervation is a feature in esophageal cancers that may be driven by cancer cell-released NGF.]]> Wed 17 Nov 2021 16:31:21 AEDT ]]> Shutting the gate: targeting endocytosis in acute leukemia https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:39597 Wed 15 Jun 2022 12:54:03 AEST ]]> CD151 (CD151 molecule (Raph blood group)) https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:6950 Wed 11 Apr 2018 15:52:55 AEST ]]> RNA modulators of complex phenotypes in mammalian cells https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:7723 Wed 11 Apr 2018 11:43:25 AEST ]]> Mechanisms of epigenetic regulation of gene expression in colorectal cancer cells https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:11905 Wed 11 Apr 2018 10:56:58 AEST ]]> Tetraspanin CD151 regulates glycosylation of α3β1 integrin https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:4527 Wed 11 Apr 2018 10:09:59 AEST ]]> Role of voltage-dependent modulation of store Ca2+ release in synchronization of Ca2+ oscillations https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:1132 Wed 11 Apr 2018 09:44:22 AEST ]]> T-helper 22 cells develop as a distinct lineage from Th17 cells during bacterial infection and phenotypic stability is regulated by T-bet https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:48779 Wed 05 Apr 2023 14:30:29 AEST ]]> p53 isoform expression promotes a stemness phenotype and inhibits doxorubicin sensitivity in breast cancer. https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54475 Tue 27 Feb 2024 14:56:31 AEDT ]]> Genome-wide base-resolution mapping of DNA methylation in single cells using single-cell bisulfite sequencing (scBS-seq) https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:32623 Tue 26 Jun 2018 11:28:33 AEST ]]> Epidermal growth factor induces tyrosine phosphorylation, membrane insertion, and activation of transient receptor potential channel 4 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:494 Thu 25 Jul 2013 09:09:56 AEST ]]> Evolutionary algorithms for scheduling a flowshop manufacturing cell with sequence dependent family setups https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:145 Thu 25 Jul 2013 09:09:48 AEST ]]> Lipidomic profiling of extracellular vesicles derived from prostate and prostate cancer cell lines https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:43246 Thu 15 Sep 2022 10:17:31 AEST ]]> Granulocyte-macrophage colony-stimulating factor is required for bronchial eosinophilia in a murine model of allergic airway inflammation https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:5196 Thu 01 Aug 2019 17:32:00 AEST ]]> Quantitative immunohistology: tissue section thickness, another glitch in the path to standardization (editorial) https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:7329 Sat 24 Mar 2018 08:35:13 AEDT ]]> TLR7 is involved in sequence-specific sensing of single-stranded RNAs in human macrophages https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:5132 Sat 24 Mar 2018 07:49:44 AEDT ]]> SIAH1 targets the alternative splicing factor T-STAR for degradation by the proteasome https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:6573 Sat 24 Mar 2018 07:49:17 AEDT ]]> Eosinophils: biological properties and role in health and diseases https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:6617 Sat 24 Mar 2018 07:46:21 AEDT ]]> Antioxidant systems and oxidative stress in the testes https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:6652 Sat 24 Mar 2018 07:46:20 AEDT ]]> Phase analysis for 2-D weakly coupled oscillatory systems https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:586 Sat 24 Mar 2018 07:43:31 AEDT ]]> The mechanism of SR95531 inhibition at GABA(A) receptors examined in human alpha(1)beta(1) and alpha(1)beta(1)gamma(2S) receptors https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:310 Sat 24 Mar 2018 07:42:41 AEDT ]]> Oncolysis of vascular malignant human melanoma tumors by Coxsackievirus A21 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:56 Sat 24 Mar 2018 07:42:01 AEDT ]]> Transdifferentiation: a plant perspective https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30522 Sat 24 Mar 2018 07:25:04 AEDT ]]> Understanding Food Allergy Through Neuroimmune Interactions in the Gastrointestinal Tract https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:53532 Mon 04 Dec 2023 15:38:04 AEDT ]]> Cold Shock Domain Containing E1 (CSDE1) Protein is Overexpressed and Can be Targeted to Inhibit Invasiveness in Pancreatic Cancer Cells https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:41096 Fri 22 Jul 2022 18:07:18 AEST ]]>